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gov/books/NBK548824/ PubMed PMID: 31644131
3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid
Tsisanova E
plays a key role in tumor cell proliferation and tumor vascularization
GGTI-298 TFA - CAS# 1217457-86-7 60002 gov/books/NBK548824/ PubMed PMID: 31644131GGTI 298 TFA, CAS No. 1217457 86 7, is a potent geranylgeranyltransferase I (GGTase I) inhibitor with potential antitumor actrivity. GGTI 298 disrupts MAP kinase activation and G(1) S transition in Ki Ras overexpressing transformed adrenocortical cells. GGTI 298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin dependent kinase inhibitors. A potential mechanism for GGTI 298 antitumor activity. GGTI 298 arrests human tumor
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