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It inhibits JARID1B (also known as KDM5B or PLU1) with an IC₅₀ of ~3 μM in vitro
3-dihydro-1H-indol-6-yl]-1H
CAS Number: 89464-63-1
12(6):681-91
Thalidomide-NH-amido-C8-NH2 hydrochloride lycosin It inhibits JARID1B (also knownThalidomide NH amido C8 NH2 hydrochloride is a synthesized E3 ligase ligand linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Product information Molecular Weight: 493. 98 Formula: C23H32ClN5O5 Chemical Name: N (8 aminooctyl) 2 {[2 (2, 6 dioxopiperidin 3 yl) 1, 3 dioxo 2, 3 dihydro 1H isoindol 4 yl]amino}acetamide hydrochloride Smiles: Cl.
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