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BAY11-7082 also reversibly activates MAPK signaling and induces apoptosis of leukemic T cell and B-cell lymphoma cell lines
but not in normal human dermal fibroblasts at concentrations up to 10 uM
2015 Nov 3
PubMed PMID: 10812087
(±)Eriodictyol - an ADAM17 inhibitor. CAS# 4049-38-1 064 BAY11-7082 also reversibly activates MAPK()Eriodictyol, an ADAM17 inhibitor, CAS No. 4049 38 1, is a potent TRPV1 antagonist. () Eriodictyol inhibits capsaicin induced Ca2+ influx in synaptosomes and exhibits antinociceptive activity in animal models without affecting body temperature. () Eriodictyol is also an antioxidant that protects against H2O2 induced neurotoxicity in vitro by activation of Nrf2 ARE signaling. Modeling studies predict binding to ACE2 preventing its interaction with
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